Clinical Application and Evaluation of Population Pharmacokinetic Parameters in Phenytoin Dosage Adjustment.
نویسندگان
چکیده
منابع مشابه
Different pharmacokinetic parameters of phenytoin in Iranian Outpatients: Need to optimize the current dosage administration
Dose-dependent pharmacokinetic of phenytoin necessitates the estimation of the maximum rate of metabolism (Vm) and the Michaelis-Menten constant (Km) in a concerned population. The aim of this study was to determine the pharmacokinetic parameters of phenytoin in a sample of Iranian patients to optimize the antiepileptic pharmacotherapy. Fourty patients who received a constant dose of phenytoin ...
متن کاملDifferent pharmacokinetic parameters of phenytoin in Iranian Outpatients: Need to optimize the current dosage administration
Dose-dependent pharmacokinetic of phenytoin necessitates the estimation of the maximum rate of metabolism (Vm) and the Michaelis-Menten constant (Km) in a concerned population. The aim of this study was to determine the pharmacokinetic parameters of phenytoin in a sample of Iranian patients to optimize the antiepileptic pharmacotherapy. Fourty patients who received a constant dose of phenytoin ...
متن کاملdifferent pharmacokinetic parameters of phenytoin in iranian outpatients: need to optimize the current dosage administration
dose-dependent pharmacokinetic of phenytoin necessitates the estimation of the maximum rate of metabolism (vm) and the michaelis-menten constant (km) in a concerned population. the aim of this study was to determine the pharmacokinetic parameters of phenytoin in a sample of iranian patients to optimize the antiepileptic pharmacotherapy. fourty patients who received a constant dose of phenytoin ...
متن کاملEvaluation of predictability for vancomycin dosage regimens by the Bayesian method with Japanese population pharmacokinetic parameters.
The predictability of serum vancomycin (VCM) concentrations by means of the Bayesian method was evaluated to establish whether the method can be used to select safe and effective VCM treatment regimens for individual patients. Serum VCM concentrations at the trough and 2 h after the end of infusion (peak) were measured. Pharmacokinetic parameters were calculated for VCM dosage regimens based on...
متن کاملWarfarin dosage adjustment strategy in Chinese population.
BACKGROUND Blood anticoagulation after heart valve replacement is a recognized difficulty all over the world. In this study, we identified the effect of amiodarone on the function of warfarin and confirmed the countermeasure by concluding the genotype distribution of vitamin K epoxide reductase complex 1 (VKORC1) and cytochrome P450 2C9 (CYP2C9) of the patient to predict the security dose of wa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Hospital Pharmacy
سال: 1993
ISSN: 2185-9477,0389-9098
DOI: 10.5649/jjphcs1975.19.1